血液净化文献资料

如果是净化血液的保健设备，是没有用的。对于慢性肾脏衰竭尿毒症患者，用血液透析机和血液透析器，对毒素和血肌酐和血尿素氮清除净化是有很大帮助的，是起到治疗作用的。毒素逐所蓄积后，经血液透析器净化，可以降低体内血液中毒素的浓度，起到净化作用。有针对高血脂过多的血液净化器，可以吸附体内，血中毒物或药物的血液灌流器，对血液净化也有帮助的。扩展资料：血液净化根据清除物质的不同，人的身体获得的好处也不一样。比如针对肾脏生理功能衰竭的患者，血液净化技术就可以清除肌酐和尿素氮。针对高血脂病症的患者，那么主要就是清除血脂，减少心脑血管发病的风险。血液滤过将血液中的大分子物质滤除掉，多用于肾功能衰竭和多器官衰竭的危重病人。有的病可单用，有的病需两者联合俯揣碘废鄢肚碉莎冬极应用。参考资料来源：百度百科-血液净化

Blood purification pharmacokinetics Shanghai Jiaotong University College of Medicine subsidiary Ruijin Hospital kidney Chen Nan-J) N FWR; t Blood purification technology in clinical treatment of acute and chronic renal failure has been nearly half a century, and in critically ill patients, such as acute renal failure (ARF) in the treatment of continuous renal replacement therapy (CRRT) more traditional intermittent hemodialysis greater advantages, its clinical application is gradually expanded from the traditional kidney renal replacement to support development, participate in a multidisciplinary critical severe _ (HwU> Whether or ARF in patients with CRF usually kinds of medication, drugs in the application of these patients should be in accordance with its residual renal function adjustment, and at the same time, blood purification and changed the drug metabolism in patients with these conditions, particularly in critically ill patients, such as failure to consider this factor, medication adjustment programmes, the consequences could be Q: bKT # \ 1) from the following three aspects of the assessment of patients with blood purification P (rS - `I First, the nature of drug j1ZFsTFMWp 1, renal clearance in the proportion of drug: drug in the body's overall clearance rate is the body organ system capacity to remove the sum of drugs, including liver, kidney, as well as other metabolic If drugs mainly through kidney removal, which is usually to remove CRRT part of the in vitro clear / removal of the overall ≥ 25 ~ 30%, it is necessary to adjust the Pio ^ 5j hB6 2, protein binding rate: drug free with biological activity and can be removed filtration, plasma protein binding is the high rate of drugs (such as digitalis glycosides drug, warfarin, ) are difficult to remove CRRT Protein binding rate can be affected by many factors, the theoretical value and the actual situation may have some ! 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"V Cefoperazone 6-5 90 14-20 1-2 q12h thoroughly after delivery without adjustment?,: # 9 Cefuroxime 2 33 13-18 75-5 q8h thoroughly after administration 0 q12h * i? RJH Ceftazidime 2 17 28-4 1-0 q8h 0 1-0 q24-48h YxE bg (Y Amikacin 4-3 <5 22-29 5mg/kg q12h 2 / 3 of the normal 30-70% q12-18h wI! + L & Q Tobramycin 5 <5 22-33 7mg/kg q8h 2 / 3 of the normal 30-70% q12h lC = N: = Mu Ciprofloxacin 3-6 20-40 5 5-75 q12h 25 q12h 2 q12h, $ h (fM8GC Levofloxacin 4-8 24-38 1-5 5 q24h 25-50% 50% + T, H & # Imipenem 1 13-21 17-3 5-0 q6h thoroughly after administration 50 percent - J "qrp Z ^ Vancomycin 6-8 10-50 47-1 5 q6h 5 q48-q24-96h 5% 48h c X: 3 30 4 losartan 50mg qd-q12h unclear hundred percent jq57C)) X 2 Benazepril 22 95 15 10mg qd not 50-75% uw K h Monopril 12 95 15 10mg qd not 100% [T'yc: = Atenolol 7 45-60 5-10 50-100mg qd 25-50mg 50% q48h s ULIrYRA The name of the drug half-life F Ze: co8Mu (H) protein binding 0zw + @ l ` (%) Vd `" a? A 5] k (L / Kg) renal function f) * NX After the normal dose HD ^ fs m6 f)) SUPPLEMENTARY of CRRT j ~ Q) F | i8 Carvedilol 5-8 95 1-2 25-50mg q12-24h not 100 percent [6AHaOhR ' Nifedipine 4-5 97 4 10-20mg q6-8h not 100%> s & XX, w Amlodipine 35-50 95 21 5mg qd not 100 percent 1p8: 1) q Felodipine 10-14 99 9-10 10mg qd not 100% gs? 8Wzh90 * Digoxin 36-44 20-30 5-8 25-5mg qd not 25-75% q36h H4t) + (: D ' Low-molecular-weight heparin 2-0 unclear 06-13 30-40mg bid unclear 100% p "2m9 0IO Warfarin 34-35 99 15 load 10-15 mg of 2-10 mg qd not iHPUmTus not -- Azathioprine 16-1 20 55-8 5-5mg/kg q24h 25mg/kg 75% yq?] V7 ~ Cyclophosphamide 4-5 14-20 5-1 1-5mg/kg qd 1 / 2 dose of 100% Z:! IX ^ q;) n Vincristine 1-5 75 5-11 4mg / sq m unclear 100% I! P4 (3skAB Prednisone 5-5 80 2 5-60mg qd not 100% X x_ tpC? Prednisolone 5-5 80 2 5-60mg qd need 100 percent OZf6/10O / A prednisone 9-0 40-60 2-5 4-48mg qd not 100 percent [@ / /) # 5v Insulin 2-4 5 15 Indefinite not 75% `([R j M` Acarbose 3-9 15 32 50-200mg tid unclear avoid / 'ZKST4 Effects of Fluvastatin small 5-1 98 42 2-10mg qd unclear 100% k O1)? DWpa Simvastatin 2> 95 mg qd unclear 5-40 unclear 100%

1、血液净化是一种用来清除血液中大分子物质的血液净化疗法。基本过程就是用高速离心机分离患者的血浆和细胞成分，可以将致病因子全部去掉，也可以选择性地去除血浆中的某些致病因子，有效去除血液中的甘油三酯，胆固醇，低密度脂蛋白，大脂肪颗粒，微聚体，重金属等有害物质。然后将血液的有效成分输回体内。2、血液净化如何去除血液中的垃圾？对身体有害的这些物质大部分都溶解于血浆之中。进入血浆里的毒物、有害药物，溶血产生的游离血红蛋白，病理释入血浆的自身抗体、循环免疫复合物、异常球蛋白、胆红素、酶、血脂、尿素氮、肌酐、血钾、血钙等。迅速解除或减轻病理损害，再通过血液净化恢复正常的血浆功能，帮助患者度过危险期，为进一步治疗创造有利条件、赢得救治时间。3、通常，可以净化出400~1000ml的血液垃圾。治疗1次，病理性血浆物质的去除率可达约95%。一般做完一次效果就非常好。4、血液净化在难治性疾病方面具有难以想象的作用。尽管其不是病因治疗，但它作为一种免疫调节或形象的比喻相当于“免疫外科切除”的治疗手段，在综合治疗涉及免疫介导的许多疾病时疗效显著，它能使症状迅速缓解，特别是一些难治之症有望安全度过危重期。5、治疗性血液净化适应症有哪些？国内国外资料报告，治疗性血液净化治疗已用于临床治疗，80--100多类疾病，一百七八十种疾病。301血液净化适合血液净化的人群:1、高血脂、高血粘度、高血压的“三高”患者。2、男性性功能障碍。3、肥胖症患者，伴有脂肪肝、高血压等病症。4、患有心脑血管疾病并发症、后遗症的患者。5、冠状动脉硬化、冠心病、心绞痛、心肌梗塞心律不齐、心衰、动脉粥样硬化、脑梗塞、脑溢血、脑萎缩、老年痴呆症、偏瘫等。6、血流异常病变，血液粘、稠、滞、淤等。7、有办公室疲劳综合症的人，如紧张、易疲劳、思维缓慢、反应迟钝、记忆力减退者。8、下肢动脉栓塞、肢体干性坏疽。9、视网膜动脉栓塞。10、有发生心脑血管疾病可能的高危人群。11、中老年人或者绝经妇女。12、有不良生活习惯的人，如嗜烟酒、喜食肉、喜高糖高盐饮食、运动量少者。13、有头晕脑沉、胸疼胀闷、喘息不畅、心悸气短、恶心呕吐、入眠打鼾、四肢酸麻沉重者。14、眼花、视力下降者。15、家族中有心脑血管疾病患者，其家庭成员则可能遗传这一病症。

血液透析(Hemodialysis，HD)通过其生物物理机制，完成对溶质及水的清除和转运，其基本原理是通过弥散(Diffusion)、对流(Convection)及吸附(Absorption)清除血液中各种内源性和外源性“毒素”；通过超滤(Ultrafiltration)和渗透(Osmosis)清除体内潴留的水分，同时纠正电解质和酸碱失衡，使机体内环境接近正常从而达到治疗的目的。