Chronic carpal tunnel syndrome caused by covert tophaceous gout: A case report

INTRODUCTION

Carpal tunnel syndrome (CTS) is the most commonly diagnosed compression neuropathy of the upper limb[1]. It is usually caused by excessive pressure on the median nerve as it travels through the wrist at the carpal tunnel. The confined anatomic space makes the nerve vulnerable to compression. The causes of CTS include local trauma to the wrist, bleeding disorders,space-occupying lesions, rheumatoid arthritis, diabetes mellitus, and multiple myeloma[1-3]. Deposition of gouty tophi in flexor tendons can also cause chronic and acute CTS. This is extremely rare, with a reported incidence of 0.6%[4]. For the patient of this case report presenting with CTS, it was particularly exceptional that he had no visible tophi in any part of the body. To our limited knowledge, the literature has yet to report tophi-associated chronic CTS in a patient who lacks visible signs of tophi but has a family medical history of gout. Here, we describe such a case of CTS without significantly visible tophi in a 25-year-old male.

CASE REPORT

A 25-year-old male who was referred to our department presented with typical CTS symptoms of his right hand.The symptoms worsened with extension of the wrist.Intermittent numbness in the three radial fingers of the right hand developed three years ago, but he did not recall a history of trauma or tophaceous gout. The patient reported no previous gouty attack. He did not accept medical treatment during the first two years. His condition worsened, and the numbness in his right hand became significantly aggravated over the previous three months before seeking treatment at our department.

Medical treatment with mecobalamin aimed to ease the numbness began three months ago, but without significant improvement. The patient had normal hand function activities but decreased grip strength. On local physical examinations, joint pain, palpable mass, and redness of the wrist and hand were absent.Obvious atrophy of the thenar muscle was also absent.Phalen’s test and Tinel’s sign were positive. Neurologic examination revealed numbness in the thumb, index finger, middle finger, and half of the ring finger of his right hand. Electromyography revealed reduced conduction velocity and impaired sensory function of the median nerve. Laboratory analyses, including complete blood count and electrolytes, were normal.C-reactive protein was elevated (17.17 mg/L), as was erythrocyte sedimentation rate (28 mm/h). A diagnosis of hyperuricemia was made with an elevated uric acid level of 568 µmol/L.

Radiographs revealed no bone erosion or tophi deposition in his hands (Figure 1). Magnetic resonance imaging (MRI) showed a sizable mass adhering to the surface of the distal volar radius with a wide base, and a mass adjacent to the digital flexor tendons at the level of the proximal carpal tunnel; this mass appeared to be pressing on the median nerve (Figure 2). The mass had low-to-intermediate signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Given the gout history of the patient’s father, and the laboratory, clinical, and imaging findings,we speculated this was a case of tophaceous gout compressing the median nerve, resulting in numbness in the hand.

On the basis of imaging findings and the failure to ease numbness through mecobalamin therapy, we decided to perform surgery two days after hospital admission. During the operation, an upper arm tourniquet was applied (inflated to 200 mmHg) without exsanguinating the extremity. A longitudinal incision was made over the carpal tunnel, distal to the wrist flexion crease and proximal to the forearm. With the transverse carpal ligament exposed, the median nerve was identified. We observed a significant bulge in the portion of the median nerve within the canal and a distal impression on the nerve (Figure 3). Large tophi were observed next to the ulnar side of the median nerve, and in the flexor digitorum superficialis and flexor digitorum profundus tendon sheaths of the middle finger, ring finger, and digitus minimus (Figure 4). With the median nerve and flexor tendons protected by the drainage tubes, large gouty tophi were found embedded deep into the distal volar radius (Figure 4). The gouty tophi had irregular boundary shapes, and their surface was soft but without inflammation or ulceration. Thus,we performed a synovectomy of all the affected flexor tendons and we removed the deep gouty tophi (Figures 5 and 6). A definite diagnosis of tophaceous gout was confirmed by the pathology report. The wound was irrigated with saline until clear effluent was observed.Epineurium neurolysis of the median nerve was then performed. Rubber drainage tubes were removed one week later.

Figure 1 Radiograhic posteroanterior projection images of the patient’s hands. Radiographs showed no bone erosion or tophi deposition.

The day after surgery, the patient reported marked lessening of numbness in the thumb, index finger,middle finger, and half of the ring finger of his right hand. We then encouraged him to actively flex and extend his hand; uric acid-lowering medication was recommended. The patient was followed closely as an outpatient under orthopedic surgery services and rheumatology services. Long-term management of gout involved daily maintenance medication with allopurinol.With respect to diet, the patient was advised to decrease consumption of meat high in purine content, high fructose corn syrup, and alcohol, especially beer.

Poor healing of surgical wounds in gouty patients is well recognized because of the phlogistic characteristics of gout[12]. This did not pose a problem in our case.Complete removal of visible and well-confined tophi,lack of inflammatory lesions, satisfactory rinsing of the area and use of uric acid-lowering agents may explain why this was averted. The disease may recur due to residual tophi. Complete removal of the tophi achieved a good result in our patient. Uric acid-lowering medication,including uricosuric agents and allopurinol, is necessary to avoid recurrence of gout[13]. The target serum urate levels should be less than 6 mg/dL[14]. Reducing the consumption of meat rich in purine content, high fructose corn syrup, and alcohol also was helpful in our case,likely because poor compliance with low-purine diet therapy and consumption of seafood and beer increases the risk of gout[7].

Six months after the surgery, the patient recovered full sensory and motor function of the right median nerve, and his uric acid level was normal. As of the 12-mo follow-up, the patient reported no gouty attacks and no recurrence of numbness. Gouty tophi in the operated hand were also absent at the 12-mo exam(Figure 7).

DISCUSSION

In the present case, surgical intervention was postponed because of a lack of imaging data and our ignorance about his family history of gout. Thus, physicians need to be familiar with tophi-associated CTS and aware of the patient’s family history of gout, as both are critical for differential diagnosis. In addition, imaging examinations, including ultrasound, CT, and MRI are recommended for an early accurate diagnosis. Surgical intervention is recommended to relieve symptoms and to avoid permanent damage.

Radiographs showed no bone erosion or tophi deposition in the hands.Magnetic resonance imaging showed a sizable mass adhering to the surface of the distal volar radius, and a mass adjacent to the digital flexor tendons at the level of the proximal carpal tunnel.

Chen et al[9] performed a retrospective CT and MRI review of patients with a documented diagnosis of gout and who presented with gout-related CTS. This review revealed that gouty tophi should be entertained as a cause of CTS in the appropriate patient population. Ultrasound has also been used in diagnosing CTS caused by gouty tophi of the flexor tendons of the fingers[10].It is well known that a delayed diagnosis can lead to irreversible nerve injury and complications, including articular changes, tendon rupture, and tenosynovitis[11].Thus, it is imperative to consider all possibilities when entertaining causes of CTS.

The carpal tunnel is a narrow rigid tube at the base of the hand composed of ligaments and bones. It encompasses the median nerve and the tendons that move the fingers. The confined anatomic space makes the nerve susceptible to compression. Tophaceous gout is a well recognized, but uncommon, cause of CTS.Tophi can be deposited in various structures, including the flexor tendons, tendon sheaths, the carpal tunnel floor, transverse carpal ligament, and even the median nerve[5]. These can cause symptoms associated with these deposits[5]. In the current case, several flexor digitorum superficialis and flexor digitorum profundus tendons were affected by tophi, and more deep tophi were found adhering to the distal volar radius.Interestingly, in this patient the pronator quadratus muscle was also affected, which had never been reported in the literature.

采取厦门市民宿POI数据，运用最邻近指数、核密度估计法、标准差椭圆法研究厦门市民宿的分布格局、集聚中心与发展方向，并分析其影响因素，发现厦门市民宿的空间分布受多种因素影响，具有明显的区域差异.

根据以上对发现，我国图书、报纸、期刊的出口数量大于进口数量，图书出口的总额是小于进口总额，但是和前几年相比之下，出口数量和金额有着明显的增长。

为了更好地完成各项工作计划，广东海事局还开展了以“平安西江·青年守卫”为主题的青年突击队共建活动。以此为契机，西江沿线六个分支海事机构积极行动，成立了以青年业务骨干为核心的各种青年突击队，引领海事青年在“平安西江”建设实践中聚焦主业、岗位建功。如2017年11月21日，由佛山海事局具体组织协调，联合广东省佛山、肇庆、中山、江门、云浮、珠海六市14家单位在西江开展的统一执法行动中，海事青年担当了主力。

In conclusion, prompt diagnosis accompanied by CT or MRI is necessary to identify the specific causes of CTS in patients with a family history of gout and medication failure. To relieve symptoms and to avoid permanent damage, surgical decompression of the median nerve and complete removal of gouty tophi are recommended whenever a patient presents with symptomatic median nerve compression. Postoperatively, uric acid-lowering therapy should be instituted.

Figure 2 Magnetic resonance images of the patient’s right hand and wrist. A: Lateral projection; B: Posteroanterior projection; C: Transverse projections.Magnetic resonance imaging revealed a giant mass adhering to the surface of the distal volar radius. The base of the mass was wide (A, B, white arrows). There was also a mass adjacent to the digital flexor tendons at the level of the proximal carpal tunnel. These were pressing on the median nerve (C, red asterisks).

Figure 3 Photomicrograph of the surgical field. After exposing the tran-sverse carpal ligament, we identified the median nerve. The section of the median nerve coursing through the carpal canal had a significant bulge (white arrow) and a distal impression (black arrow).

Figure 4 Photomicrograph of the surgical field, with the wrist rotated medially. An impressive large mass (3.2 cm in diameter; black arrow) was observed on the ulnar side of the median nerve (MN); in the flexor digitorum superficialis and flexor digitorum profundus tendon sheaths of the middle finger, ring finger; and in the digitus minimus. With the median nerve and flexor tendons protected by the drainage tubes, we observed another large mass(7.0 cm in diameter; white arrows) embedded deep into the distal volar radius.The masses were irregularly shaped and their surface was soft but without inflammation or ulceration.

Figure 5 Synovectomy of all affected flexor tendons was performed and deep masses were removed.

Figure 6 Chalk-like liquid was found in the gouty mass.

ARTICLE HIGHLIGHTS

Case characteristics

Tophaceous gout.

历年来，平塘县洪灾多为县境河流上游邻近县乡镇发生强降雨、洪水快速汇流所至。当日上午，平塘县防办通过山洪灾害监测预警平台监测到县内各乡镇及县城六硐河上游都匀市墨冲、凯口一带降雨情况后，根据水文判断，县城至六硐坝区将发生50年一遇的洪灾，及时将情况报告县委县政府，同时及时启动防洪应急预案。在此次洪灾过程中，仅15～16日，平塘县防办利用山洪灾害监测预警平台向县有关部门领导、乡镇行政首长、水库管理单位负责人、各行政村支书主任、水利系统干部职工等发出预警转移信息7次2 800多条，提醒全县上下注意防御山洪灾害。在县城供电中断的情况下，县防办及时启用山洪灾害应急供电系统，确保了工作的正常进行。

Clinical diagnosis

Numbness in the thumb, index finger, middle finger, and half of the ring finger of the right hand. The symptoms worsened with extension of the wrist. Normal hand function activities with decreased grip strength.

Figure 7 Magnetic resonance imaging of lateral projection of the patient’s right wrist. Magnetic resonance imaging showed no recurrence of gouty tophi 12 mo after synovectomy of all the affected flexor tendons, removal of deep gouty tophi, and epineurium neurolysis of the median nerve of the patient’s right wrist.

Differential diagnosis

A young man with a family history of tophaceous gout who presented with typical carpal tunnel syndrome symptoms.

Laboratory diagnosis

Complete blood count and electrolytes were normal. C-reactive protein,erythrocyte sedimentation rate and uric acid level were elevated.

Imaging diagnosis

Carpal tunnel compression may be the initial manifestation of gout[6]. Because of its rare frequency,gouty involvement of the flexor tendons and CTS may be overlooked in the differential diagnosis[7]. It was particularly exceptional for this patient, because there were no visible tophi in any part of his body. Gout is more likely to develop in patients whose family members have had gout. It is possible that their genetic makeup predisposes them to gout[8]. Since our patient reported no problem with overconsumption of alcohol,no history of gout, and no visible tophi when he visited our department for local examinations, we diagnosed him as a typical CTS patient. He took mecobalamin but experienced little relief for months. Given the imaging findings and his father’s history of gout, gouty tophi were finally considered to be the likely cause of CTS.

Pathological diagnosis

Tophaceous gout in the digital flexor tendons.

Treatment

Surgical removal of the gouty tophi, synovectomy of all the affected flexor tendons, and decompression of the median nerve were performed.

2018年11月28日下午，北京石景山警方通报，歌手陈羽凡因吸毒、非法持有毒品被行政拘留。人生明明如“彩虹”，为何要“画地为牢”？作为公众偶像，若不能树立正确榜样，所谓“最美”，顿时黯然失色。毒品贻害无穷，必须冷酷到底。人生总要奔跑，但千万别跑错了方向。

综上所述,这些传统的提取方法在提取过程中都存在反应时间长、提取不充分、产品得率并不理想的问题,同时这些方法会使细胞组织结构丧失选择性,从细胞内渗透出的不仅有被提取成分还会混入较多杂质,导致提取成分很难与杂质分离。

Related reports

To our limited knowledge, this is the first case report to describe tophiassociated chronic carpal tunnel syndrome without visible signs of tophi but has a family medical history of gout.

Term explanation

Carpal tunnel syndrome is the most commonly diagnosed compression neuropathy of the upper limb, which is usually caused by excessive pressure on the median nerve by many causes. Deposition of gouty tophi in flexor tendons is a rare cause.

Experiences and lessons

Tophaceous gout is a rare cause of carpal tunnel syndrome (CTS). Physicians need to be familiar with tophi-associated CTS and aware of the patient’s family history of gout. Prompt imaging examinations including computed tomography or magnetic resonance imaging are necessary to identify the specific causes of CTS.

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